I would say isolated refers to the fact of being separated from others, and doesnt really progress to how one may feel about it, good or bad.
Pygmalion, you just kinda assumed that no one ever really connects with anyone else - i think thats a flaw in your reasoning here. And ending your argument with "doesnt that make sense?" - this isnt a math proof. I cant tell you how many times ive used that line with my therapists ("doesnt that make sense?") only to be shot down.
Get out there and connect!!!
"use it before you lose it" is a real thing.