My pdoc prescribes me varying doses of Seroquel during an episode to knock out the agitation mainly. To begin with I can usually tolerate high-ish(~400mg spaced out through the day) doses and be barely tired. It is once it starts to knock me out that I know I am getting better as the Bipolar isn't pushing so hard against it. I tend to slowly wean off it over weeks/months after that based upon my response. However, this is when it is not being used as a mood stabiliser but for severe agitation and insomnia/hypomania.