I went off my meds (I know, silly) for a while and I lost so much weight in that time, I was actually happy with my weight. I'd never taken Seroquel before. I then had a relapse and had to go back on medication, then my new psychiatrist put me on 450mg Seroquel, which is my current dose I have been taking for a few months. Within 3 weeks I gained back all of my weight. I've always been a stress eater, but even when I was not eating at all in those first 3 weeks, I still gained so much. As long as you and your doctor monitor it, I think you'll be okay. But yes I find it definitely puts on weight and also increases my appetite.