I've been on Seroquel XR for about 6 1/2 years and gained 20 lbs, most gained in the last two years when at 600 mg per day. Prior to that, my average daily dose was 350 mg. Then I was also on Geodon and Lithium. It is hard for me to lose weight at the 500 mg + level, but I think that at 450 mg and below, it's mostly weight neutral.

It is highly possible that some of my weight gain would have happened without medications. After all, I had reached a weight 10 lbs less than I am now about 16 years ago, before ever taking daily meds. Being overweight is common in my family. I also stress eat during some periods. I have done that throughout my life.

I have struggled with high cholesterol for some years now. I know my weight contributes to that, but probably Seroquel XR itself might, too. My blood pressure has mostly be perfect all of this time. My other test results are either just a little high, or sometimes normal, depending on my diet. Just the cholesterol is stubborn.

In the past (maybe 12 years ago), I had taken regular Seroquel at doses up to 800 mg. I found regular Seroquel to be more of a weight gainer than my Seroquel XR of 6 1/2 years. I'm not sure why. My guesses are that often I took regular Seroquel twice per day vs. once per day, like I take the XR. Also, something maybe to do with the release of the medication. "Spikes"? I tend to do better and have milder side effects on extended release medications.