Thought I'd weigh in here since coincidentally, I just got off a trial of Rexulti and Abilify. I could definitely tell a difference between the two, although they are similar. Rexulti helped more with depression, but made me restless and a bit agitated. Abilify made me feel almost giddy and not agitated at all, but I think it may have even been causing some mania in me. I was super focused at work, but felt like I always had to be doing something.

Between the two, I liked Rexulti better, although neither worked out for me. I would probably have to take a mood stabilizer with either of them in order to stay on them. Everyone has a different reaction, though, so it may be completely different for you.