I have been having this same battle with Seroquel. I have gone off and on it at least 7 times because of weight gain. Unfortunately it seeens to be the only thing that works for me. So I have gained 100 pounds over the last 6 years or so. I hate being obese. It makes my bad knee hurt worse and I have no stamina. Why do we have to choose between our mental and physical health? I am on Metformin but it doesn’t appear to be doing anything. Just these past couple of weeks I have gained 2 more pounds. I just don’t know what to do anymore. I can’t go off the Seroquel again. I was even thinking about raising it. It is really a no win situation for me at the moment. The weight is starting to effect my mood because I was always in shape and an athlete growing up. Now I won’t even allow my picture taken.