No, yes, maybe.

Socially - When people try to get close to me, they don't seem to understand that I can't reciprocate any sort of bonding. When that fact finally sinks in, they tend not to react very well. A lot of people have also told me that they find it hard to know the "real" me. Counterintuitively, this gets more frequent as I try to be open about myself. So yeah, it can make close personal relationships a bit difficult.

Professionally - There's usually enough distance that people don't try to form these close bonds. Nonetheless, given enough time, some people can still "see through the mask," as it were, especially if they find me in a different social context.