I take a med cocktail for depression w/bipolar "features" and lately I just don't feel that great. Two of my meds are activating: Adderall, which was prescribed for relentless fatigue/depression several years ago and Fetzima. I was taking the Fetzima for three months but started feeling really jittery and anxious; I think it was due to the interaction between the Fetzima and Adderall. I stopped taking the Fetzima several days ago and now I'm not feeling so good. The nervousness is gone but my mood isn't so good and I'm irritable. I also take 15 mg Remeron and Geodon at bedtime and wonder if increasing the Remeron would improve my mood. I'm nervous about calling my doctor b/c she probably won't be pleased that I stopped 80 mg Fetzima cold turkey. I'm not sure what to do but something's got to change. Has anyone noticed improved mood on higher doses of Remeron?