Hello stuff: Welcome to Psych Central.  Here are links to 2 articles, from Psych Central's archives, on the subject of treatment resistant depression which may be of interest to you:
About Treatment Resistant Depression (TRD)
What You Need to Know About Treatment-Resistant Depression
I hope you find PC to be of benefit. 
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"I may be older but I am not wise / I'm still a child's grown-up disguise / and I never can tell you what you want to know / You will find out as you go." (from: "A Nightengale's Lullaby" - Julie Last)
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