My experience with zyprexa is not a good one. I was on it for several years despite my side effects. Most noticable one was weight gain. I gained maybe 40 pounds on it. (Some credit must be given to Depakote for weight gain also.) Lithium gave me hypothyroid which added to metabolic syndrome. But the worst thing zyprexa did to me was weight gain which contributed to non-alcoholic fatty liver disease. My metabolism has come to a crawl from zyprexa's effects also which only adds to the fatty liver. Unfortunately, fatty liver leads to cirrhosis of the liver which is a hardening of the liver. Fortunately, your liver can repair itself, but cirrhosis CAN kill you.