I was in a clinical trial for lamotrigine. I was first put on the placebo (it was obvious as I got so much worse I only stayed out of IP by lying) then in a later phase of the trial was put on it as a known med. It worked for me at a high dose but I vomited every day and eventually we stopped it. I think I was on it about a year.

I tried it again later when it was more obvious that I was going to have a lot of trouble finding meds that worked. This time it worked almost immediately and I felt better than I had in a long time. I passed the highest risk period for the rash and was still doing great. Two weeks later I developed the rash on my face, lips, right by my eye, and down onto my neck. No more lamotrigine for me.