It definitely sounds like your wife has the symptoms of depression. I know when I hit my lowest stage, I couldn't get out of bed for a long time, I had no motivation to clean, and my husband was constantly frustrated by the state of the house, which made me feel worse because I was failing him as well as myself. It got to a point where I had the suicide prevention line on speed dial.

Have you tried getting to the source of this behavior? It could be a cry for help.