Ditto for me. They do nothing good for me at all. They always either make me manic , manic with mixed features, or some crazy form of ultraradian cycling. The last time I attempted to take an antidepressant, my psychiatrist himself warned against it (my stupid therapist at the time told me to ask for a particular one). Reluctantly, my psychiatrist prescribed it and it was a total mistake, indeed. Prior to that, some IP and IOP psychiatrists tried prescribing antidepressants WITH moodstablizers AND antipsychotics, and I ended up IP again and again. I only found longer-lasting stability when antidepressants were removed from my cocktail once and for all. I haven't taken an antidepressant for 8 years and I haven't been in the hospital for 8 years. That doesn't mean I haven't had manias since then, but they were easier to contain with medications like Seroquel XR and other antipsychotics. Frankly, depression hasn't been much of an issue for me since then, anyway.