Years ago I was only diagnosed with depression and anxiety (not bipolar) and Nortriptyline and Effexor both helped me. Since being diagnosed as being on the "bipolar spectrum" I have done well on Cymbalta combined with Zyprexa, Cymbalta combined with Geodon and am currently OK on Remeron with Geodon but not as good as I've been in the past, so my doctor is adding in Lamictal soon. (As an aside, I haven't been thrilled with my doctor lately so things are subject to change!)

Other antidepressants I've tried include Prozac, which was OK but not very effective and Wellbutrin which I had high hopes for and don't recall why it didn't work well for me.