Hi EmJay,

Welcome to the PC Bipolar forum.
I hope you will find the information and the support you may be seeking.

It certainly seems like there are relatively new thoughts about chronic treatment resistant depression and BPII.. it sounds like you might have had a couple of episodes of hypomania? Agitation/irritability can definitely be a part of BPII. I often experience irritability when my mood is shifting. The treatment goal is to stabilize mood so it does not easily shift into various types of episodes.

It is unfortunate you are experiencing so much anxiety. That does not feel good.
I see you are on a few meds, including klonopin. I believe the klonopin is meant to treat anxiety. If it is not working well enough, please do persist in getting a response from your pdoc.

Do you have any idea as to why your pdoc might not respond?
Does he have colleagues in his office? Maybe get in touch with them and explain that you need your doctor's help right away?

Benadryl. Many use this for anxiety and/or for sleep.. I cannot recommend it and I cannot sing its praises. I am not a licensed health care professional.. I do have some concerns about you using Benadryl without your pdoc's permission My concern is that you are adding a med to your already long list of meds. and have no professional input regarding any interactions, etc.

With several meds on board, it could be very difficult to know if there may or may not be any interactions, despite what the literature says.

Please do be careful mixing/adding meds, even OTC meds.

It is critical your pdoc responds to you, asap. Please keep reaching out. There has to be some way to get to him? Please do check with your pharmacist regarding any drug interactions of concern. :hug;