BipolarWolf, I completely understand what you're going through. For 4 months now I have lost interest in absolutely everything. Seroquel gave me some relief as far as insomnia, and seemed to lift me ever so slightly from my darkest thoughts of self-harm. Yet, I still cannot seem to find joy in any of the things that I do when not depressed. To top it off, the smallest everyday tasks are OVERWHELMING to me (grocery shopping, cooking, going to my son's soccer games, making lunches for the kids for school, taking a shower, cleaning...) I rarely ever find anything on tv that interests me. And making decisions is so difficult, even easy stuff. It's ridiculous!. I have also just started (on my 2nd day) a new AD, Wellbutrin, after Lexapro was a total failure. I pray we both find some relief very soon.