Hello Zeilaram: I see this is your first post here on PC. So... welcome to Psych Central. In the addition to the Depression forum, here on PC, there is a sub-forum dedicated to the subject of treatment resistant depression. Here's a link just in case you hadn't already noticed it:

https://psychcentralforums.com/treat...nt-depression/

You mentioned you've been dealing with depression on-&-off for over 30 years. So I thought I would draw your attention to this Psych-Central-supported website for people with unrelenting depression & anxiety:

Project Hope & Beyond

And then here are links to 5 articles, from Psych Central's archives, that (hopefully) may be of some help:

About Treatment Resistant Depression (TRD)

What You Need to Know About Treatment-Resistant Depression

Tips for Finding Motivation When You're Depressed

https://blogs.psychcentral.com/relat...hen-depressed/

https://psychcentral.com/blog/3-stra...dium=popular17

I hope you find PC to be of benefit.