Sertraline made me psychotic as well as partially catatonic (though some of that catatonia was preexisting). It's the only time I've ever been psychotic. I wasn't cognitively able to read - the symbols had no meaning. And I didn't speak for a week. And I believed my mother had been replaced by a robot and was dangerous. And a host of other crazy effects. Basically completely destroyed me. I am 100% sure it was the sertraline because I was on no meds before that and no other type of change.

Wellbutrin lifted me out of depression very quickly, like within two days, and then kept going and pushed me into hypomania. Pdoc stopped me from taking it at that point but I'm sure it would have taken me into mania. Also, it gave me a terrible headache.

Prozac made me hypomanic constantly even on a tiny dose.

I switched pdocs due to moving and my new pdoc said never take any antidepressant ever again, and list them as a drug allergy.