I've gained about 25 lbs from meds (and possibly due to hormonal changes from menopause). I've had to buy new clothes. I am supposed to taper off of Remeron once I've tapered up on Lamictal, so I'm hoping I can lose weight then. I lost 7 lbs pretty quickly (in a week or two) when I stopped Remeron before. I'm exercising as much as I can; I walked for 30 minutes yesterday and today I worked out at the gym. My cholesterol is high and I wonder if my meds contribute to this. I often struggle with low energy and even take a stimulant to help this but it doesn't always help. I'm hanging in there!