I was on both Wellbutrin and propranolol and did fine. I do think the beta blocker helps a bit with anxiety for me, but I do not get too anxious on the Wellbutrin, fortunately. But I feel that is a secondary issue in what you are saying. As BirdDancer notes, the propranolol is no kind of replacement for lithium, a powerful mood stabilizer. Do you plan to add another mood stabilizer if you are going to d/c the lithium? I really hope you speak with your pdoc about all this. Going off any mood stabilizer if you are a person who needs one can be quite dangerous (I have personally suffered the consequences). I hope you talk to your pdoc. There are lots of other mood stabilizers and they all have their own side effect profiles.