I tried weaning off Seroquel this past April because I was convinced that my pdoc had told me to. (I still kinda think she did!) After a few weeks I morphed into mania and finally was "caught" by my case manager. She talked to my pdoc who prescribed something like 450 mg of seroquel. It landed me flat on my back! Three hours of sleep in the day felt like 5 minutes! Ive since gone back down to 150. And now my Haldol is increased PRN because of scary vivid "intrusive thoughts". It has helped a lot but it makes me dozey. Even so, I have it in my purse just in case. If the increased Seroquel hadn't worked, my pdoc said, She would've sent me inpatient.