i have panic disorder and ptsd... i was on wellbutrine too... but was increased to 300mg... it helped at the higher dose until i tried the generic and i had a really bad reaction... made the panic much worse... i don't know about bipolar... but now i am on effexor and it seems to be really helping with my anxiety. my doctor had wanted me to take abilify for the anxiety... it is prescribed off label for ptsd... but it is approved for bipolar .... i wanted to try the effexor first because i felt uncomfortable using it for something it wasn't approved for...my med doc said it was really good and didn't have the weight gain issues... that it works on a different part of the brain and helps with anxiety in patients that don't respond to other drugs... good luck...lyn