Hi BipolarWolf, I’ve been on 70 different meds since 2014. We finally found that serequel, Valium’s, gabapentin, Effexor worked well. I’ve been on this combination for several months. But now, it feels that it’s not working. I’m thinking that I might be one of those people who are med resistant. I meet with my therapist next week. Also, I meet with my psychiatrist next week too. Thanks for your reply. Oh, I asked my wife to pray for me and she said no. Will you say a prayer or send positive thoughts.?