I'm like Pookyl. I, too, experience some negative effects from missed doses. I'm talking even just an individual medication. If I miss all in my morning or evening piles, it's even worse. If I skipped my evening meds, I would not sleep. Period. That usually brings on mixed feature type symptoms. Just missing a 0.5 mg Klonopin isn't nearly as bad.

This is a real issue for some. Sometimes I forget that I'm running low on meds until too late. Usually on a Friday night. Of course! Then they have to order them. They never have certain meds in stock. When you are struggling to think clearly, it can be rough managing multiple medications with various refills left, running out at different times.