I was never opposed to medication. I was diagnosed with depression and anxiety for 20+ years before my current doctor diagnosed me as being on the bipolar spectrum. It made sense b/c I'd definitely have hypomanic irritability while taking antidepressants. I took the first antidepressant that was prescribed to me 30 years ago, Nortriptyline. When I went to see my current doctor I was open to taking the antipsychotic and antidepressant she prescribed b/c I was in a severe dysfunctional depression. I didn't mind the weight gain side effect for awhile because I went from not functioning/lying on the sofa to running my household, cooking, being a much more involved mom, working out every day, etc.