I don't have schizoaffective disorder. I have bipolar type 1 that leans in the manic depression. I have had my share of psychosis and also depression. For me, Seroquel XR has been my main medication. I do take other bipolar medications, as well, but believe Seroquel XR is the main one for me.

My dose of Seroquel XR is 600 mg. Most all websites state the following for people with bipolar type 1. Average doses as monotherapy or adjunct to Lithium or Depakote are:

* Bipolar depression - 300 mg

* Mania/Maintenance - 400 mg to 800 mg

Obviously people do well on other doses other than "average doses", above or below, or take it only for sleep, usually at lower doses. Plenty of people take it as an adjunct to other meds instead of Lithium or Depakote. In my case, my Seroquel XR might be slightly higher than it otherwise would need to be because of how it interacts with Tegretol. Maybe.

Regular Seroquel has the same averages above, but is often given twice a day instead of once. I find some minor differences between the two in terms of my tolerability. I highly doubt that I would do as well taking the regular Seroquel only once per day. XR is the right choice for me.

Abilify was temporarily helpful for a past depression, but not my mania. I know it was for others. I forget my past dose.