I don't have schizoaffective but I do have severe bipolar. Clozapine has changed my life immensely and I am so glad I ran out of viable med options and went on it. I'm almost at 4 years out of the hospital and I've stayed able to cope through things like my father's death. I'm even able to break out of my shell a bit and go to church and a group through church. Those are huge things for me. I haven't had a severe episode since starting. The one time I started going mixed 4 days of a 25 mg increase kicked its' butt. That never happened with other meds, even heavy sedatives.

I know it's not a first choice but if you need it it is good stuff.