I’ve gained 75 lbs on Seroquel over the last 6 years and 95 lbs total on psych meds. I had lost 45 a couple of years ago but when my doctor had to significantly increase my Seroquel and depakote, I gained it all back. I am soooo embarrassed about my weight and it is so hard to lose! It doesn’t help that until recently my husband would constantly criticize and comment about it. He has finally learned how disrespectful and hurtful that is though and he stopped.