There is one glitch that I know of with Spybot, in that it lists something called DSO exploit everytime you run it, even if that particular problem has been eliminated. I don't know if that problem has been corrected yet.

I was rather obsessed with spyware/adware problems for awhile.... it was a major problem at first... have Adaware, Spybot, Pest patrol (subscription), and Webroot Spy Sweeper (subscription). These days, I don't seem to have any more problems. Spybot and Spysweeper block all known problems, and AOL has its own spyware searcher now.