I had periods during my almost 14 years of bipolar treatment when I was lethargic most of the day, and others just the opposite. On my current mix, as long as I take them regularly, including my evening meds no later than 7 or 8 pm, I am just fine.

I am not quite the Energizer Bunny now at nearly 50 years old that I was when I was younger, but that's kinda understandable. I'm sure my Seroquel XR slows me down, but I don't really feel tired. I do get tired at night gradually, but I see that as understandable, too.

It took some time for my body to adjust to my Seroquel XR, but it did.

Lamictal never made me lethargic. It was activating for me. I'm only on 20 mg Latuda. It seemed to clear my thinking rather than cloud it.