Thanks for your reply. Sounds like you got your meds under control which I think is awesome. Seroquel has been a life saver for me. Gotta love that drug! I see you are on a rather high dose too. I'm on 750 mg per night. I've been struggling recently so I take just about 50 mg of my night dose during the day to get me through. Makes me feel a little high and drowsy but it's better than the alternative SI which scare me immensely. Needless to say, I'm home a lot. Trying to stay busy and ward off the depression. I've decided not to take any more antidepressants and see if I can just keep my night meds. My doc said the Seroquel and Trazodone do work for depression. Hate to think of the alternative that has been suggested to me - that being ECT. Take care and have a great day!