Thank you so much for this, @BethRags. I am going to ask my pdoc about Prystiq. I don't think he has ever even mentioned it. I wonder why? I am also ready for ECT, if it becomes necessary. I would rather do that than go on Clozaril, which is the other thing being currently discussed. The side effects freak me out.

I may get in trouble for saying this and I am not saying it cannot work for some people, but in my experience being on it for several years and talking to other folks who have taken it, I just think Lamictal is overrated for bipolar depression. I don't think it did a damn thing for me besides putting me in the burn unit for a week. Just my take and, of course, everyone's mileage does vary. But I had to get that off my chest because I believe Lamictal is pushed on us too hard as some kind of panacea for depression. And I don't believe it is.