Well, it is several weeks since I replied to this earlier post - my fatigue from 20 mg Lexapro has disappeared (except for the few hours at night when it helps me sleep. I found that I could cut back on my Xanax and that helped the sleepiness. So, your body does adjust to it and it does help with the anxiety as well. However, I have noticed the weight gain which does not make me feel happy, but better than a little upset over my weight than consideirng suicide from the depression without the meds.