Has your doc checked your thyroid to make sure there isn't something out of balance?

I gained weight on Zoloft, but probably only because I wasn't eating much before because of my depression.

I lost a huge amount of weight (well, huge for me anyway) on Wellbutrin. But it was kind of like speed for me. It made me really shaky.

I'm on Cymbalta and Xanax XR now. Pdoc just upped my Cymbalta to 90mg from 60mg. Those two meds certainly affect my appetite a lot. I forget to eat or don't want to eat. But that just happens to be how those meds affect me. With the extra 30 mg of Cymbalta, I am back to force-feeding myself.

Different meds affect people differently.