I hear ya about the bad bloodwork results. I have high cholesterol and sometimes high triglycerides, too. However, I don't really think my weight gain has been significant at all, on Seroquel XR. I am overweight and I'm sure that losing weight would improve my cholesterol and triglycerides, but if they were normal, I'd be fine with where I am. That doesn't mean that I don't think my Seroquel XR is weight friendly. But it's not particularly unfriendly, for me. I'd say that at doses up to about 450/500 mg, my Seroquel XR was weight neutral for me. At my current 600 mg, it's slightly harder, though. I've been on 500 mg or more for at least five or six years. I've gained 20 lbs since, which I think I could have gained even with no meds. I managed to lose almost 10 lbs once on 500 mg, but then mental chaos kind of reversed that a bit. I've mostly maintained since. My point? Have you ever talked to your doc about the "XR" version? I found it to be a bit more weight friendly than the regular Seroquel. I suppose that could just be me. I've kind of found the hunger "spike" to be lower with the "XR", especially at doses under 600 mg. Even at 600 mg, my appetite is not extreme, as long as my mood is OK. Often it's my mood that is my biggest weight enemy.

I guess we're all just different. I've read others say they gained 100 lbs on Seroquel XR.

My psychiatrist once attempted to put me on Metformin. Many people lose weight on that med. I had to stop almost immediately because I happen to have kidney damage from Lithium. Metformin is contraindicated for people with kidney damage.

When I'm a little sped up, I tend to lose weight because I'm burning more calories quicker. I don't recommend inducing hypomania or mania, but if a person is depressed, or stable but oversedated, a dosage or med change may help. You've got to be careful about being too speedy too long, though. It can be physically damaging. My brother was told that he had been living with tachycardia so long that it exacerbated his heart problems. I take a beta blocker for tachycardia. My brother and I have always been physically speedy type people. My sister, on the other hand, has always been physically slow as molasses.So is my husband. Sometimes I wish I could just drag him with me, he's so slow. I leave him in the dust!