Before I started taking CBD Oil, I checked with my pharmacist to make sure there was no drug interaction with my medication. Once he said everything looked fine, I started off on 250 mg. Since then I have increased it to 1000 mg. It does seem to relax me some. But not really that much. I find valarian root works better for me. I guess it just depends on your chemistry. And I get even more relaxation out of a daily meditation routine.