Thanks for all of your replies. I went to see my pdoc yesterday to discuss my ability to handle to 112.5 mg dose. I have been doing better since i started and I recently went back to work on Monday for the first time in 2 months. However, yesterday when I saw my pdoc she wants to up my meds again from 112.5 to 150 mgs. She also took my blood pressure and said it was 120 over 80 and said that was normal. She also wants me to get blood work done. This freaked me out a little and I was up most of the night imagining the worst about the blood test and what it all means. I couldn't sleep so needles to say I had to take yet another day off from work. I feel like such a loser. I don't know why I always have to assume the worst and take things to the max. Anyway, i'm to continue the 112.5 mgs of effexor through Sunday then 150 mgs starts next monday on 02/14/05. I will be ok... Won't I?