My Emsam did at first but we were able to balance it out with meds and I don't have any anxiety now that I would attribute to the med (it's been 10 years now). I've used a combination of klonopin and gabapentin. I'm coming off klonopin with the world's slowest taper, so far .5 mg in about 15 months. I started tapering and my father got sick and died. I got past that, tapered again and a family member got cancer and I'm anxious about him so another taper is a ways off. Thankfully my pdoc is in no rush and knows pushing me off while dealing with the excess stress won't work.

I think the first while I was on vistaril along with the other meds (gabapentin either not used yet or at a much lower dose than now). It helped.