Pookyl, I'm sorry about all of the extra weight you need to contend with. And I totally understand that feeling of wanting to rebel against diets. Has your doctor considered maybe adding a more weight friendly medication in addition to the Seroquel, as a means of slowly lowering the Seroquel dose? I see in your signature (if it's still up-to-date) that you're on three antipsychotics (two of which are Seroquel). How does the Saphris work for you? Is that weight neutral? Saphris is a medication I have never personally tried. I do know Seroquel XR and regular Seroquel quite well. I take a very small dose of Latuda as another antipsychotic. My guess is that Latuda is more helpful at keeping my bipolar depression away than curbing/preventing mania. Every time I start to get hypomanic or manic, my Seroquel XR dose goes up, or I take regular Seroquel as a prn.