I have been on Zoloft for many years, and it does help; WITH the addition of mood stabilizers. When I was initially seen by my primary physician many years ago, I was put on Zoloft. It perked me up. Too up. I started seeing a Pdoc shortly after, and we added Lithium and Depakote. Lithium is great. Depakote did nothing for me.

Years later, when it seemed like Zoloft was petering out, we tried a switch to Wellbutrin. Instant Manic. Irrational, rage, seeing things. I obviously switched back to Zoloft. I tried Effexor, with about the same result as Wellbutrin with the addition of sexual side-effects.

As you know, meds affect all of us differently. For me, Zoloft has been a great med overall. I have been taking Zoloft, Lithium and Lamictal for quite a while now and it's the best combo I've found. For Me.