Thanks for your help and response still_crazy! I do hope I can get down to 1 antipsychotic. The Seroquel has been amazing when it comes to helping me sleep and some mood stabilization. The Latuda has been helping a little bit with more stabilization. But there's definitely risks to staying on both at the same time, which you explained. Sleep is such a big factor for me, because I have struggled with insomnia my entire life, and if I don't sleep, I get manic or hypo. Yesterday, my pdoc decided to lower my Latuda, just a bit, to see if the side effects are less worse. That would be best-case-scenario, because maybe I won't get the twitching---or at least not as much with the decrease, while still getting some of the mood stabilization effect. Plus, I am on very high dose Lamictal and clonazepam (occasionally Xanax). So I am hoping for the best. I'm sure a long the way there will be more changes, like when mania occurs. I've been more depressive lately with some mixed features along the way.

I've also been on Abilify, but only for a brief period of time, so I do not have much memory as to why that was changed. My pdoc said that would be her next-in-line choice for me, if I'm not benefiting enough from Latuda. Other one she would consider are Lithium being second next-in-line, followed by risperdal or olanzepine if those ones fail, with exception of maybe trying Abilify or if push came to shove then Lithium. I definitely want to avoid the olazepine and risperidol. I don't like the idea of being on antipsychotics, but they do help with symptoms.

Has anyone else here experienced sexual side effects on AP's? This has never been a problem for me until Latuda was added. Seroquel and Abilify did not cause this. I don't want to deal with sexual dysfunction forever, so Latuda just might not be the med for me to stay on long-term. Only until I'm a bit more stable. Sorry for the long post...I've just been struggling with these changes and needed to put it out there.