I used to be on 600mg of seroquel but it wasn't helping my manic episodes so I was changed over to Abilify 15mg and Thorazine 400mg. I'm also on a moodstabilizer. This has been the best combo I've been on, very stable, my Psychotic symptoms are 100% gone. When my doctor first mentioned Thorazine I was scared but a lot of the side effects people get from it are from back in the day when it was prescribed at ridiculously high doses. It's been super effective for me, much more so than seroquel and I don't have any side effects. It helps with sleep too.