Modafinil obviously serves many people well, including people with bipolar disorder. However, there are some people (like myself) that have mania triggered by it. It's good to be careful and have people on the lookout for possible mania triggered from it. I will say that the manias I've had triggered by Modafinil (Provigil) were strangely cut short when that drug was suddenly stopped. That was a unique situation for me. Usually my manias are like snow balls rolling down a mountain gaining speed and size.