I have such a varied reaction/tolerance to meds. It's frustrating.

I can take 150mg Seroquel for a month or two and then, suddenly, I cannot function at all on just 25 mg.
The same happens with gabapentin.. Can take 1200mg for awhile. Cannot tolerate even 100mg later on.
It's safe to say this happens with most prn meds.

I think this must be do to a change in mood?
Anyone else have this in an ongoing manner? Uggh!