Never had to give a cat a topical med. I've nebulized hundreds of cats and some hated the box but most did alright. I've given meds in liquid form with a syringe most of them I'd wrap in a towl and hold them just so and put the liquid in the side of the mouth. That was harder but most were pretty sick as I volunteered in the intensive ward at the shelter. But topicalls, nope. I can't imagine they'd be too happy with that.