if you're Bipolar I leans more towards the Schizoaffective category, I could maybe see taking the risks (?), mainly because the available info on zyprexa -does- indicate -some- benefits in Schizophrenia. at the time of the...I think it was called the CATIE study, maybe...zyprexa came in 2nd to clozapine, for those with a diagnosis of Schizophrenia.

bipolar I, bipolar II? I dunno. The zyprexa+prozac combo pill, symbyax (I think all strengths are generic now, in the US) has been studied for Bipolar I depression and for "treatment-resistant depression" (" " because...I find the term subjective...), with good results. -If- an antidepressant+"atypical" is going to be on the menu, then I would consider symbyax or adding generic zyprexa to generic prozac, simply because the data is there, which is not so much the case for other antidepressant+"atypical" combinations. but...

weight gain, metabolic complications...sedation, a certain 'flatness'...these are all fairly common with zyprexa. to be fair, the 'atypicals,' as a class, mix a reduced risk of -some- of the problems from the old drugs (flatness, apathy, anhedonia, lethargy, tardive dyskinesia, Parkinsonism, acute EPS) with their own fabulous set of "issues," usually involving weight and/or metabolic complications, so...

zyprexa is notorious, as well it should be, but its not the only 'offender' in the 'atypical' category.

my personal major concern is that you're on 2+ neuroleptics, in addition to other treatments. not to keep on nit picking, but what little data is available on 2+ neuroleptics over the long haul is mostly for people with long-term and/or severe Schizophrenia. I'm a PubMed geek, so I've reviewed a couple small meta-analyses, and...most of the data deals with clozapine in the mix, too, so...like so, so many of us, you're entering an evidence-free zone, in terms of risks vs benefits. blah. psychiatry :-(

ok. hope this helps a bit, maybe. :-)