I am on Lithium, Tegretol and Seroquel. I have been on Seroquel for over 10 years and like it. It really helps calm my mind and helps me sleep.

It can cause fatigue, but if you take it early enough or split up the dose it will be ok. Also, that side effect disappears after awhile.

The biggest problem I have had with Seroquel is weight gain. Most everyone I know has gained like 20-50 pounds on this medication. It is also related to increases in blood glucose levels...which may be related to the weight gain or might be a separate side effect.

There are also some other anti-psychotics that can be used for Bipolar that do not cause as much weight gain....such as Abilify and Risperdal. You might try these as well.

Good luck