Hi Moose. I don't have much experience with Haldol. The only time(s) I received it was in the form of an intramuscular injection when I was psychotic inpatient. I believe it calmed that. I don't recall it putting me to sleep.

I do have a great deal of experience with both Seroquel iR and Seroquel XR. Seroquel XR has been part of my evening mix for several years now. I also have a supply of Seroquel iR for "prn" use. Prior to 8 years ago, I had taken larger doses (up to 800 mg) of the iR, at times. Also as a "prn", I have Ativan 1 mg pills.

What I notice as a difference between Seroquel iR (aka "regular") and Seroquel XR (extended release) is pretty understandable. Both can help me sleep, but I'd say that the "iR" is definitely quicker action. It seems to reach a higher peak of sedation quicker and then fall quicker. The sedation "peak" of Seroquel XR seems a little lower, but it stays there for longer. My evening dose of Seroquel XR is 600 mg. I only have 50 mg pills of the iR for "prn". The problem with 50 mg iR, is that it doesn't make me that sleepy anymore (or much sleepier). I can easily take 50 mg iR during the daytime, and though it does calm agitation and other mild manic symptoms a bit, it doesn't make me sleepy. It has helped a little at 50 mg at night (added to my 600 mg XR), but frankly, the 1 mg of Ativan helps me get to sleep even better, when my usual mix falls short. I don't know exactly why. Like the 50 mg Seroquel iR, Ativan 1 mg doesn't make me sleepy during the daytime. I have had larger dose Ativan injections (don't know dosage) during the daytime, when manic in the hospital. That has knocked me out quickly and intensely, but no one really wants to depend on Ativan for sleep.

I guess the only way you'll know which is better for sleep (Seroquel or Haldol) is to compare them. Did your psychiatrist specify a dose or range of doses to take for "prn" use? Mine has.