I was on 150mg of effexor once a day no side effects. I still felt depressed and it wasn't proving my suicidal ideation. So I was taken off of it and out on another med, I don't remember what the other was. But then my psychiatrist and I'd ecided I was better of effexor but might need something to help more as well. So i restarted 150mg effexor and it gave me TERRIBLE heat/nausea flashes.