From what I know of the research, SSRIs don't usually push people into mania, but they do lower the threshold for mania. So, it's related, but not a definite. When I've been on SSRIs in the past they haven't pushed me to the manic side. Sometimes they help with the depression, and in one case it made me more depressed. I'm on Lamictal and Latuda as well. The Latuda seems to act as my antidepressant. I was on Wellbutrin mostly for focus issues, but then I changed to a different medication. In general, though, I'd think it's safe to be on an SSRI, especially in conjunction with a mood stabilizer and an antipsychotic. Obviously, though, talk with your doctor about your anxieties and concerns.